Publications

Direct links to select peer-reviewed journal articles regarding ceragenins can be found below:

  1. Ceragenins are active against drug-resistant Candida auris clinical isolates in planktonic and biofilm forms. Marjan M. Hashemi, John Rovig, Brett S. Holden, Maddison F. Taylor, Scott Weber, John Wilson, Brian Hilton, Aaron L. Zaugg, Samuel W. Ellis, Connor D. Yost, Patrick M. Finnegan, Charles K. Kistler, Elizabeth L. Berkow, Shenglou Deng, Shawn R. Lockhart, Marnie Peterson and Paul B. Savage (2018).
  2. Preclinical testing of a broad-spectrum antimicrobial endotracheal tube coated with an innate immune synthetic mimic. Marjan M. Hashemi, John Rovig, Jordan Bateman, Brett S. Holden, Tomasz Modelzelewski, Iliana Gueorguieva, Martin von Dyck, Ronald Bracken, Carl Genberg, Shenglou Deng and Paul B. Savage (2017).
  3. Candidacidal Activity of Selected Ceragenins and Human Cathelicidin LL-37 in Experimental Settings Mimicking Infection Sites. Bonita Durnaś, Urszula Wnorowska, Katarzyna Pogoda, Piotr Deptuła, Marzena Wątek, Ewelina Piktel, Stanisław Głuszek, Xiaobo Gu, Paul B. Savage, Katarzyna Niemirowicz, Robert Bucki (2016).
  4. Bactericidal Activity of Ceragenin CSA-13 in Cell Culture and in an Animal Model of Peritoneal Infection. Robert Bucki, Katarzyna Niemirowicz, Urszula Wnorowska, Fitzroy J. Byfield, Ewelina Piktel, Marzena Watek, Paul A. Janmey, Paul B. Savage (2015).
  5. CSA-131, a ceragenin active against colistin-resistant Acinetobacter baumannii and Pseudomonas aeruginosa clinical isolates. Xavier Vila-Farrés, Anna Elena Callarisa, Xiaobo Gu, Paul B. Savage, Ernest Giralt, Jordi Vila (2015).
  6. Bactericidal Activities of Cathelicidin LL-37 and Select Cationic Lipids against the Hypervirulent Pseudomonas aeruginosa Strain LESB58. Urszula Wnorowska, Katarzyna Niemirowicz, Melissa Myint, Scott L. Diamond, Marta Wróblewska, Paul B. Savage, Paul A. Janmey, Robert Bucki (2015).
  7. Local Delivery of the Cationic Steroid Antibiotic CSA-90 Enables Osseous Union in a Rat Open Fracture Model of Staphylococcus aureus Infection.  Aaron Schindeler, PhD, Nicole Y.C. Yu, PhD, Tegan L. Cheng, BE/BMedSci, Kate Sullivan, PhD, Kathy Mikulec, Lauren Peacock, Ross Matthews, BVSc, Dip Vet Clin Path, and David G. Little, FRACS(Orth), PhD (2015).
  8. In Vitro Bactericidal and Bacteriolytic Activity of Ceragenin CSA-13 against Planktonic Cultures and Biofilms of Streptococcus pneumoniae and Other Pathogenic Streptococci. Miriam Moscoso, María Esteban-Torres, Margarita Menéndez, Ernesto García (2014).
  9. Optimization of Ceragenins for Prevention of Bacterial Colonization of Hydrogel Contact Lenses. Xiaobo Gu, Jacob D. Jennings, Jason Snarr, Vinod Chaudhary, Jacob E. Pollard, and Paul B. Savage (2013).
  10. Study of the effect of antimicrobial peptide mimic, CSA-13, on an established biofilm formed by Pseudomonas aeruginosa.  Carole Nagant, Betsey Pitts, Philip S. Stewart, Yanshu Feng, Paul B. Savage & Jean-Paul Dehaye (2013).
  11. In vivo efficacy of a silicone‒cationic steroid antimicrobial coating to prevent implant-related infection.  Dustin L. Williams, Bryan S. Haymond, James P. Beck, Paul B. Savage, Vinod Chaudhary, Richard T. Epperson, Brooke Kawaguchi, Roy D. Bloebaum (2012).
  12. Effect of a low concentration of a cationic steroid antibiotic (CSA-13) on the formation of a biofilm by Pseudomonas aeruginosa. C. Nagant, Y. Feng, B. Lucas, K. Braeckmans, P. Savage, J.P. Dehaye (2011).
  13. Ceragenins: A Class of Antiviral Compounds to Treat Orthopox Infections.  Michael D. Howell, Joanne E. Streib, Byung Eui Kim, Leighann J. Lesley, Annegret P. Dunlap, Dianliang Geng, Yanshu Feng, Paul B. Savage and Donald Y.M. Leung (2009).
  14. Antimicrobial Activities of Ceragenins against Clinical Isolates of Resistant Staphylococcus aureus. Judy N. Chin, Michael J. Rybak, Chrissy M. Cheung, and Paul B. Savage (2007).

Direct links to select articles relevant to the ceragenin technology and N8 Medical’s products under development can be found below:

  1. AMR: a major European and Global challenge.  European Commission (2016).
  2. The interconnection between biofilm formation and horizontal gene transfer. Jonas Stenløkke Madsen, Mette Burmølle, Lars Hestbjerg Hansen, Søren Johannes Sørensen (2012).
  3. Electron microscopic analysis of biofilm on endotracheal tubes removed from intubated neonates.  Karen B. Zur, MD, David L. Mandell, MD, Ronald E. Gordon, PHD, Ian Holzman, MD, and Michael A. Rothschild, MD (2004).
  4. Biofilms and device-associated infections. Rodney M. Donlan (2001).